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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NPM1 All Species: 21.82
Human Site: S143 Identified Species: 60
UniProt: P06748 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P06748 NP_002511.1 294 32575 S143 L S I S G K R S A P G G G S K
Chimpanzee Pan troglodytes XP_001151859 290 32094 S139 L S I S G K R S A P G G G S K
Rhesus Macaque Macaca mulatta XP_001092017 289 31951 S143 L S I S G K R S A P G G G S K
Dog Lupus familis XP_536432 294 32601 S143 L S I S G K R S A P G S G S K
Cat Felis silvestris
Mouse Mus musculus Q61937 292 32542 S143 L G M S G K R S A P G G G N K
Rat Rattus norvegicus P13084 292 32542 S143 L G M S G K R S A P G G G N K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508370 280 30882 D156 D E E E D D E D D E D D D E D
Chicken Gallus gallus P16039 294 32614 A145 N A S T K R P A S G G G A K T
Frog Xenopus laevis P07222 299 33514 A145 P K N A K R I A P D S A S K V
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.6 97.2 98.3 N.A. 93.5 93.5 N.A. 76.8 69.7 65.5 N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.6 98.3 99.3 N.A. 97.6 97.6 N.A. 87.4 84 79.2 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 80 80 N.A. 0 13.3 0 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 0 46.6 20 N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 0 12 0 0 0 23 67 0 0 12 12 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 0 0 12 12 0 12 12 12 12 12 12 0 12 % D
% Glu: 0 12 12 12 0 0 12 0 0 12 0 0 0 12 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 23 0 0 67 0 0 0 0 12 78 67 67 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 45 0 0 0 12 0 0 0 0 0 0 0 0 % I
% Lys: 0 12 0 0 23 67 0 0 0 0 0 0 0 23 67 % K
% Leu: 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 12 0 12 0 0 0 0 0 0 0 0 0 0 23 0 % N
% Pro: 12 0 0 0 0 0 12 0 12 67 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 23 67 0 0 0 0 0 0 0 0 % R
% Ser: 0 45 12 67 0 0 0 67 12 0 12 12 12 45 0 % S
% Thr: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 12 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _